Ambroxan®

Synthesis route :

Ambroxan® is a molecule synthesized from laevorotatory Sclareol, obtained from Clary Sage Absolute. The first step in this synthesis is to oxidize Sclareol into a lactone called Sclareolide, in its dextrorotatory form. The second is a hydrogenation of this compound into a diol. The last step is dehydration to obtain Ambroxan® (laevorotatory), the final product. Sclareolide in its racemic form can also be obtained by a purely synthetic route. Therefore, its laevorotatory isomer must be separated before the synthesis of Ambroxan®. Nowaday, there is a better process to obtain Ambrofix. This molecule can be obtained throught a unique multi-step bioconversion process starting from sugar cane. This new process is considered as the most sustainable process for Ambrofix in the market.All carbon atoms of the bio-based starting material are ending up in the product – no Carbon wasted leading to optimal carbon efficiency. Also, it needs 100x less land use to produce 1 kg of the Ambrofix compared to the traditional route based on Clary Sage This new bioconversion route maintains the classification as 100% Naturally Derived. ''

Synthesis precursor :

Ambroxan® is not a precursor to the synthesis of another compound of olfactory interest.

Isomerism :

The Ambroxan® most often used in perfumery is the laevorotatory isomer of this molecule. Ambrox DL (dextrorotatory and laevorotatory) refers to a racemic mixture of all the isomers of this molecule. The latter, however, is more unstable, as Ambrox tends to return to its laevorotatory form (L). Ambroxan® is a constitutional isomer of Cedramber®, Muscenone® and Sandela®. Cedramber® and Sandela® also have a woody, even ambery note for Cedramber®, but Muscenone® is a pretty different musk.